Endocrine Abstracts

The absolute protein level of hormone receptors is a crucial determinant for cellular responsiveness towards hormone exposure. In that respect, it is important to note that, by recent progress in gene expression profiling techniques, a novel class of small non-coding RNAs has been discovered. These non-coding transcripts of approximately 21 nucleotides are called microRNAs (miRNAs) that downregulate protein levels in a cell by translational repression. Given the increasing and...